Topic:

Warning Letters

Latest Headlines

Latest Headlines

FDA warning letter lays out cross-contamination issues at Canada plant

In April, Health Canada closed an active pharmaceutical ingredient repackager in Toronto and had it recall hundreds of bulk APIs that the regulators said could have been cross-contaminated by penicillin. Now the FDA has weighed in with a warning letter for the company.

FDA lashes Czech company for shipping contaminated APIs to U.S.

The FDA issued an import alert in April banning all human and veterinary antibiotics and other drugs coming out of a plant in the Czech Republic. A warning letter the FDA posted this week to its website explains why. Vuab Pharma was shipping active pharmaceutical ingredients (APIs) to the U.S. that were contaminated with bacteria and didn't even have tests that were capable of detecting it.

Report: Claris Lifesciences injectables sale may hit roadblock by FDA Form 483

The Business Standard of India reports plans by Claris Lifesciences to sell its generic sterile injectables business may be thwarted by an adverse observation letter the company is reported to have gotten from the FDA.

Chinese API maker cited with second FDA warning letter

The FDA may be having difficulty getting inspectors stationed in China, but that has not stopped it from issuing warning letters to drug and ingredient makers there who have issues. The agency posted a second warning letter today for API maker Yunnan Hande Bio-Tech, which was previously cited in 2010.

UPDATED: Hospira gets yet another warning letter, this one for Italy plant

Hospira has just picked up an FDA warning letter for a plant in Italy, meaning it now has plants tagged with warning letters on four of the 7 continents: Europe, North America, Asia and Australia. But the problem will be Pfizer's to deal with since it has struck a $15 billion deal to buy the sterile injectable specialist.

Ban on Aarti plants follows FDA warnings

It has been more than a year and a half since the FDA issued a warning letter for two plants in India owned by Aarti Drugs. But the drugmaker has yet to meet FDA expectations and so the agency has now put them on an import alert, banning them from shipping products to the U.S.

Hospira's new India plant again faulted by the FDA

The opening of Hospira's new plant in India that it is counting on to lower its manufacturing costs will be delayed again after it racked up another set of observations during a reinspection by the FDA last month. Unless quickly resolved, it will be an issue that Pfizer will inherit given its $15 billion buyout of Hospira announced last month.

Wockhardt hit with new FDA concerns at banned plant

FDA inspectors returned to a Wockhardt plant in Waluj that it banned in 2013 and weren't impressed by what they found during the weeklong inspection. New concerns were raised.

China's Novacyl Wuxi gets FDA warning letter

The FDA has issued a warning letter to a Chinese plant that makes active pharmaceutical ingredients for having suspect testing data after finding a failed test result in the trash and discovering the computer record of it had been overwritten. The letter comes as the agency is working to get more inspectors into the country, which has become the go-to producer of cheap APIs for the global market.

UPDATE: Cadila Pharmaceuticals API plant slapped for faulty follow-up on stinking APIs

When India's Cadila Pharmaceuticals got complaints from customers about some of its APIs smelling bad, the drugmaker decided the odor stemmed from an impurity, so it tweaked the manufacturing process. The problem, according to the FDA, is that the plant never conducted an investigation to determine whether the impurity was in fact the cause, so the company never knew whether it had really resolved the cause of the stench.